Mfundo Vilakazi rose from the bench to separate the two teams with a goal four minutes from time as Kaizer Chiefs claimed a 1-0 victory.
The 19-year-old profited from Sekhukhune United captain Linda Mtambo losing possession to send a curler from just inside the box and hand Chiefs the win.
His goal came just two minutes after Babina Noko had defender Vuyo Letlapa red-carded for his dangerous tackle on Vilakazi.
Amakhosi won 1-0 and their three points lifted them from position seven to five on the standings and Sekhukhune remained fourth on the table.