Pirates are bidding for their first Champions League title since 1995 and sailing past MC Alger would be crucial in boosting their chances of collecting the continental title.
Their PSL rivals Sundowns last won the Champions League in 2016 and over the years, playing in Africa has been their top priority.
Interestingly, Masandawana coach Miguel Cardoso will be facing his former club Esperance with whom he helped knock Sundowns out of last season's edition before reaching the final.
Should Pirates qualify for the semi-finals, they will face either Pyramids or AS FAR.
If Sundowns reach the last four, they will have to deal with either Al Ahly or Al Hilal.