Miguel Cardoso's former club, their quarterfinal opponents Esperance Sportive de Tunis, fired coach Laurentiu Reghecampf this week with the Romanian tactician lasted only four months before being dismissed, creating instability ahead of their clash with Cardoso's side.
Media reports have suggested that Maher Kanzari will replace the Romanian in the dugout and his first fixture in charge will be Cardoso's Sundowns.
This fixture comes immediately after the Fifa international break, and the Portuguese coach will hope to use it to regain momentum after their recent defeat to Orlando Pirates.
Meanwhile, Stellenbosch FC will benefit from playing at home for the first time in the competition, having previously used Moses Mabhida and Loftus Versfeld as alternative venues.
The international break will also allow South African clubs to regroup, but coaches will be wary of potential injuries to key players returning from national team duty.