After impressing midweek against Burton Albion, Marcus Rashford retains his spot on the left as United look to maintain their unbeaten start to the season.
Anthony Martial again misses out on a starting place despite a positive performance in midweek, with Rashford, Henrikh Mkhitaryan and Juan Mata all chosen behind Romelu Lukaku as they were in the 4-0 victory over Everton last Sunday.
Mauricio Pellegrino's Saints also keep the same side which won last weekend, with their 1-0 win over Crystal Palace at Selhurst Park having been only the second game in which they have scored in all competitions so far this term.
Southampton Forster; Cedric, Yoshida, Hoedt, Bertrand; Romeu, Lemina; Redmond, Davis, Tadic; Long. Subs: McCarthy, Austin, Ward-Prowse, Van Dijk, Gabbiadini, Hojbjerg, Pied.
Manchester United: De Gea; Valencia, Bailly, Jones, Young; Matic, Fellaini; Mata, Mkhitaryan, Rashford; Lukaku. Subs: Romero, Martial, Lingard, Smalling, Carrick, Blind, Herrera.
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