Having scored crucial goals against Chelsea and Anderlecht within the last two weeks, Marcus Rashford will pose the greatest threat for the Red Devils in the view of bet365, who price him at 15/2 (8.50) to break the deadlock and 12/5 (3.40) to strike anytime.
After grabbing just a fourth Premier League goal of a frustrating season against Burnley at the weekend, Anthony Martial can be backed at 5/2 (3.50) to add to that tally in more high profile fashion in the derby.
Despite failing to find the net in any of the last five matches against City, Wayne Rooney’s record of 11 derby goals is the best of any player in the fixture’s history.
Also on the scoresheet at Turf Moor on Sunday, the captain is available at 3/1 (4.00) to re-enact his derby day heroics with a potentially crucial goal here.
While Rooney’s record in these matches may be impressive, Sergio Aguero’s return of eight goals in just 10 games against the neighbours deserves almost equal admiration.
Considering he has struck 12 goals in his last 12 club appearances, the Argentina international looks like the strongest bet at 10/3 (4.33) to open the scoring, not to mention 20/21 (1.95) anytime odds.
Hoping to recover in time for the big game, Gabriel Jesus is on offer at 13/10 (2.30) to mark his return from injury with another goal to add to his burgeoning reputation in English football.
Having scored the second in his side’s 2-1 victory at Old Trafford back in September’s reverse fixture, Kelechi Iheanacho offer another excellent option for Pep Guardiola and is also available at 13/10 (2.30) to hit the back of the net.