Pitso Mosimane-coached Esteghlal were thrashed 3-0 by Saudi Arabian champions Al Hilal at the Kingdom Arena in Riyadh on Monday night.
Former Newcastle United centre forward Aleksandar Mitrovic was in his element as the Serbian star grabbed a hat-trick to earn Al-Hilal their fourth successive victory in this season AFC Champions League.
Brazilian superstar Neymar, who recently returned from a long-term injury, came on in the 57th minute and Mosimane reacted by introducing forward Arman Ramezani, but Mitrovic sealed Al Hilal's win when he netted in the 74th minute.