Mamelodi Sundowns were drawn in Group F against European giants Borussia Dortmund, Brazilian side Fluminense FC and Ulsan HD FC from South Korea.
The tournament will be staged in the United States of America from June 15 to July 13 2025 with 11 cities hosting the matches.
Masandawana open their campaign against Ulsan HD as they seek to reach the knockouts.
Former Sundowns coach Rhulani Mokwena, who is now in charge of Wydad AC, will face his role model, Pep Guardiola's Manchester City in Group G.
While Bafana Bafana vice-captain Percy Tau's Al Ahly and South African winger Elias Mokwana's Esperance de Tunis also discovered their group stage opponents.