The two Soweto giants, Kaizer Chiefs and Orlando Pirates, face significant injury and suspension challenges ahead of their midweek fixtures.
Amakhosi are set to face Magesi, while Orlando Pirates travel to Mbombela for a clash with TS Galaxy.
José Riveiro's side remains unbeaten in five league games and holds a two-point lead over Mamelodi Sundowns, aiming to extend their streak.
For Chiefs, Nasreddine Nabi must reshuffle his defense as Inacio Miguel is suspended, disrupting the backline’s consistency for the first time this season.
This situation opens opportunities for Given Msimango and Thatayaone Ditlhokwe to step up.
Chiefs will be traveling to Polokwane for the third consecutive time, looking to bounce back after two consecutive league defeats.
Both sides now find themselves under pressure, and the coming matches will test their depth and resilience.