Mamelodi Sundowns hosted AmaZulu at Lucas Moripe Stadium on Tuesday night.
Miguel Cardoso made seven changes, with Ronwen Williams returning as goalkeeper. Arthur Zwane set up his team defensively, creating a lackluster first half with few chances.
The game opened up in the second half when AmaZulu switched to an attacking approach, leaving gaps at the back.
Peter Shalulile capitalized, scoring his 127th league goal before club-record R62 million signing Arthur Sales sealed the win after turning well in the box before firing past goalkeeper Veli Mothwa.
Sundowns secured three points and extended their lead at the top to 18 points over second-placed Orlando Pirates.