The hosts return to the top table of European football for the first time since the 2011-12 season, ending a six-year hiatus, and they face a difficult task against the Premier League side.
Spurs may not have the same level of pedigree as their Serie A counterparts, but Mauricio Pochettino's men have shown glimpses of their quality in recent seasons, recording wins over Real Madrid and Borussia Dortmund.
|Game||Inter vs Tottenham|
|Date||Tuesday, September 18|
|Time||5:55pm BST / 12:55pm ET|
TV Channel, Live Stream & How To Watch
In the United States (US) the game will be available to watch live on television via Galavision and it can be streamed live online using B/R Live.
|US TV channel||Online stream|
The game can be watched live on television in the United Kingdom (UK) via BT Sport 3 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 3||BT Sport app|
Squads & Team News
|Goalkeepers||Handanovic, Berni, Padelli|
|Defenders||Vrsaljko, De Vrij, Ranocchia, Miranda, Henrique, D'Ambrosio, Skriniar|
|Midfielders||Gagliardini, Vecino, Nainggolan, J. Mario, Asamoah, B. Valero, Perisic, Brozovic, Candreva|
|Forwards||Icardi, L. Martinez, Balde, Politano|
Sime Vrsaljko and Lautaro Martinez are injury concerns for the Nerazzurri and are not expected to play any part in the game. Mauro Icardi has returned to the starting line-up.
Inter XI: Handanovic; Skriniar, De Vrij, Miranda, Asamoah; Brozovic, Vecino, Politano, Nainggolan, Perisic; Icardi.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Alderweireld, Vertonghen, Sanchez, Aurier, Davies|
|Midfielders||Dier, Son, Winks, Lamela, Wanyama, Sissoko, Alli, Eriksen, Lucas, Dembele|
Hugo Lloris will miss the game through injury, meaning Michel Vorm will continue between the posts in his absence. Dele Alli is also not likely to be involved after sustaining an injury on international duty with England, while Moussa Sissoko is also unavailable. Pochettino has confirmed that Kieran Trippier and Toby Alderweireld have not travelled to Milan.
Heung-Min Son returns to the Spurs XI after his successful run with South Korea in the Asian Games, and will make his first start of the season for the club after a pair of substitute appearances.
Vincent Janssen and Juan Foyth are long-term injury absentees and not included in the club's panel for the competition.
Tottenham XI: Vorm; Aurier, Vertonghen, Sanchez, Davies; Dier, Dembele, Lamela, Eriksen, Son; Kane.
Betting & Match Odds
Interestingly, Tottenham are slight favourites to win the game, with bet365 giving odds of 8/5 on the Premier League side. The hosts, Inter, are rated 2/1 to win and a draw is available at 9/4.
Inter and Tottenham are both facing similar problems of form ahead of their meeting in the Champions League, so they will each be hoping to use the game as a springboard for improvement.
Having finished fourth in Serie A last term, Luciano Spalletti's side are currently struggling at the wrong end of the table with just one win from their opening four matches.
They come into the game against Spurs on the back of a disappointing home defeat to Parma, which has left the Nerazzurri licking their wounds.
"It's a painful defeat," Spalletti told reporters of the loss to Parma. "When you find yourself with four points from four games in front of this crowd and considering the fixture list, it becomes difficult to find excuses.
"We did well for long spells, we were always in their half but we certainly need to offer more than what we did. The responsibility is mine above all if a lot of players are showing less than their full potential."
"I am not a person who suffers too much. I try to find the solution," said the Argentine in the aftermath of the Liverpool game.
"Don't worry for me – we need to be worried for the real things. I am so good, I am so happy.
"We started the season with good results, but we knew the circumstances and the reality after the World Cup were completely different.
"I was relaxed and not worried and today I am relaxed and not worried. My faith in this group of players is 200 per cent, not 100 per cent."