With Mbappe having scored 25 goals for Madrid and Erling Haaland on 20 strikes in 20 games for City, the game was expected to be a showdown between the two most ferocious strikers in Europe, who are also set to face off in the World Cup next year when France take on Norway.
Mbappe ran riot when Madrid met City in last season's competition, scoring a hat-trick in a 3-1 win at the Bernabeu in the second leg of the knockout play-off and also netting in the 3-2 victory in the first leg at the Etihad Stadium. Haaland struck twice in the first leg but missed the second leg due to injury and has failed to score in his previous two visits to the Spanish capital.
"At the end of the day, we must defend as a unit and show serious defensive commitment," said Madrid midfielder Aurelien Tchouameni. "We're up against a top side with Haaland, and his current form is unbelievable. If we play at our best level, we can win this game. We will talk about the game plan with the coach now.
"We have a lot of injured players in defence, but we have a lot of players who can perform at a high level in that position. They're an excellent team, especially on the ball. They like to have the ball, and we'll have to be very compact both when we defend and when we have the ball to create chances."