The Carolina Panthers head west to State Farm Stadium on Sunday, Sept. 14, for a Week 2 matchup with the Arizona Cardinals.
Carolina is trying to shake off a sluggish 26–10 defeat to the Jacksonville Jaguars, a result that left the Panthers with losses in six of their past eight outings and staring at the possibility of an 0–2 start. They’ll need a sharper effort to avoid digging a deeper early-season hole.
Arizona, meanwhile, rides in with a bit of momentum after springing a 20–13 upset on the road against the New Orleans Saints. The Cardinals have gone 3–3 across their last six contests and will look to keep that balanced stretch trending in the right direction on their home turf.
| Date | Sunday, September 14, 2025 |
| Time | 1:00 pm ET / 12:00 pm CT/ 10:00 am PT |
| Venue | State Farm Stadium (Glendale, Arizona) |
| TV Channel | CBS |
| Streaming | Fubo (Try for free), Paramount+ |
| Buy Tickets | Stubhub |
| Odds | Panthers +240 | Cardinals -300 |
Arizona Cardinals vs Carolina Panthers roster & injury news
Arizona Cardinals team news
For Arizona, Kyler Murray is off to a sharp start, completing 72.4% of his passes for 163 yards with two touchdowns and no turnovers. Marvin Harrison Jr. and Trey McBride have teamed up for 132 receiving yards and a touchdown, while Tip Reiman has chipped in with a lone catch.
The Cardinals’ rushing attack is humming along at 146 yards per contest, led by Trey Benson’s 69 yards on eight carries. On defense, Arizona is giving up just 13 points and 315 yards a game. Budda Baker leads the squad with 10 tackles, Baron Browning owns a sack, and Will Johnson has already tallied three pass deflections.
Cardinals Injury Report : Will Hernandez, G - Questionable , Zaven Collins, LB - Questionable , Joey Blount, S - Questionable , Cody Simon, LB - Questionable , Justin Jones, DT - IR
| Position | Players |
|---|---|
| Offense | Jacoby Brissett, Kyler Murray (QB); Trey Benson, James Conner, Emari Demercado, Bam Knight (RB); Greg Dortch, Marvin Harrison Jr., Zay Jones, Xavier Weaver, Michael Wilson (WR); Elijah Higgins, Trey McBride, Tip Reiman, Travis Vokolek (TE); Evan Brown (C); Isaiah Adams, Hjalte Froholdt, Jon Gaines II, Will Hernandez (G); Kelvin Beachum, Josh Fryar, Paris Johnson Jr., Jonah Williams (OT) |
| Defense | L.J. Collier, Darius Robinson (DE); Calais Campbell, PJ Mustipher, Dante Stills, Dalvin Tomlinson (DT); Baron Browning, Jordan Burch, Zaven Collins, Akeem Davis-Gaither, Owen Pappoe, Cody Simon, Josh Sweat, Xavier Thomas, Mack Wilson Sr. (LB); Denzel Burke, Kei'Trel Clark, Will Johnson, Elijah Jones, Max Melton, Garrett Williams (CB); Budda Baker, Joey Blount, Kitan Crawford, Dadrion Taylor-Demerson, Jalen Thompson (S) |
| Special Teams | Chad Ryland (PK), Blake Gillikin (P), Aaron Brewer (LS) |
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Carolina Panthers team news
Bryce Young has struggled to find his rhythm, connecting on just 51.4% of his throws for 154 yards, one touchdown, and a pair of interceptions. Tetairoa McMillan and Chuba Hubbard have combined for 100 receiving yards and a score, while Ja’Tavion Sanders has hauled in two passes.
On the ground, Carolina is averaging 113 rushing yards per outing, with Hubbard pacing the backfield at 57 yards on 16 attempts. Defensively, the Panthers are yielding 26 points and 378 total yards per game. Tre’von Moehrig tops the tackle chart with 11 stops, Mike Jackson has a pass breakup, and Jaycee Horn has snagged an interception.
Panthers Injury Report : Ikem Ekwonu, OT - Questionable , Tershawn Wharton, DT - Out , Patrick Jones II, LB - Questionable , Damarri Mathis, CB - IR , Jalen Coker, WR - IR
| Position | Players |
|---|---|
| Offense | Andy Dalton, Bryce Young (QB); Rico Dowdle, Trevor Etienne, Chuba Hubbard (RB); Dalevon Campbell, Jimmy Horn Jr., Xavier Legette, Tetairoa McMillan, David Moore, Hunter Renfrow, Brycen Tremayne (WR); Mitchell Evans, James Mitchell, Ja'Tavion Sanders, Tommy Tremble (TE); Austin Corbett, Cade Mays (C); Brady Christensen, Robert Hunt, Damien Lewis, Chandler Zavala (G); Ikem Ekwonu, Taylor Moton, Yosh Nijman (OT) |
| Defense | Derrick Brown, A'Shawn Robinson (DE); Bobby Brown III, Cam Jackson, Tershawn Wharton (DT); Claudin Cherelus, Thomas Incoom, DJ Johnson, Patrick Jones II, Bam Martin-Scott, Christian Rozeboom, Nic Scourton, Princely Umanmielen, Trevin Wallace, D.J. Wonnum (LB); Akayleb Evans, Jaycee Horn, Mike Jackson, Damarri Mathis, Chau Smith-Wade, Corey Thornton (CB); Tre'von Moehrig, Lathan Ransom, Demani Richardson, Nick Scott (S) |
| Special Teams | Ryan Fitzgerald (PK), Sam Martin (P), JJ Jansen (LS) |
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Arizona Cardinals vs Carolina Panthers head-to-head record
The Cardinals and Panthers have squared off 21 times overall, three of those in the postseason, with Carolina holding a decisive 15–6 advantage in the all-time series.
Watch and live stream Cardinals vs Panthers in the USA
The Arizona Cardinals vs the Carolina Panthers game in Week 2 of the 2025 NFL season will be broadcast live nationally on CBS. Fans will be able to catch the coverage onFubo (Try for free today!) and Paramount+.
More details on where to watch the game in the United States, including streaming options, will be released soon, so keep an eye out for our dedicated coverage.
Watch and live stream Cardinals vs Panthers worldwide
For fans outside the U.S. looking to stay plugged into the action,NFL Game Pass on DAZN is the ultimate ticket. It serves up more than 200 regular-season and playoff matchups, complete Super Bowl coverage, plus access to NFL Network, NFL RedZone, and plenty more to keep you locked in all year long.
To bypass regional restrictions or to access the game if you are travelling abroad, you can watch the action using a Virtual Private Network like ExpressVPN.
How to buy Cardinals vs Panthers tickets
The showdown between the Cardinals and Panthers is set for State Farm Stadium in Glendale, Arizona, a venue that packs in up to 63,400 fans and promises a fiery atmosphere on game day.
Tickets are already up for grabs on StubHub, with entry starting at $386. From there, prices climb through the tiers — $300, $400, $500, $600, $700, $800, $900, $1,000, and stretching all the way into the premium ranges of $2,000, $3,000, $4,000, $5,000, $6,000, and topping out at $10,406 for the best seats in the house.
Check the link below for the full breakdown of how to purchase tickets to NFL games.
READ MORE: NFL 2025 Tickets: Prices, deals, season tickets & membership information
Cardinals vs Panthers Fantasy Football
For fantasy football, Cardinals QB Kyler Murray is a solid QB8 start, projected for 19.2 points, riding the boost of home-field advantage and a favorable matchup against a shaky Panthers defense. Meanwhile, Panthers QB Bryce Young is a risky QB29 option after a rough Week 1 and facing a stout Arizona pass rush.
At running back, Chuba Hubbard remains a top-tier RB1 with 15.6 projected points, carrying the bulk of the offense. Cardinals RB James Conner (16.4 W2 projected fpts) is a reliable RB11 choice, contributing both on the ground and through the air. For wide receivers, Cardinals WR Marvin Harrison Jr. (13.9 W2 projected fpts)slots in as a WR3/flex with a favorable matchup, while Panthers rookie WR Tetairoa McMillan (13.5) looks like a WR3 lock after commanding a 27% target share in his debut. Panthers WR
Fantasy Takeaways:
- Start Cardinals QB Kyler Murray and RB James Conner with confidence.
- Lock in 49ers RB Christian McCaffrey as an elite RB1.
- Target Panthers WR Tetairoa McMillan and Cardinals WR Marvin Harrison Jr. as WR3/flex starters.
- Approach Panthers QB Bryce Young cautiously due to matchup and early-season struggles.
- Cardinals D/ST ranks as a strong streaming option over the Panthers defense.
Cardinals vs Panthers Game Predictions
Looking to Week 2, the numbers tilt the other way: Arizona is favored with a 65.2 percent chance to win, while Carolina sits at 34.5 percent, with the tiny remainder reserved for a possible stalemate.
Carolina’s opening-week effort was rough, arguably the worst showing in the league. Now the Panthers must contend with a Cardinals offense that thrives on a punishing ground attack and just watched stars Marvin Harrison Jr. and Trey McBride put up big performances. Expect Arizona to seize control early, likely building a two-score cushion and forcing Bryce Young and the Panthers’ sputtering offense into a frantic chase they’re unlikely to overcome.
Cardinals vs Panthers Betting Odds
Spread
Panthers +6.5 (-105) | Cardinals -6.5 (-115)
Moneyline
Panthers +240 | Cardinals -300
Total
OVER 44.5 (-110) | UNDER 44.5 (-110)
More NFL news and coverage
- Cardinals 2025 NFL schedule: TV channel, livestream & where to watch the games
- Panthers 2025 NFL schedule: TV channel, livestream & where to watch the games
- How to watch and live stream NFL football for free and without cable
- 2025 fantasy football rankings: Running back (RB) | Wide receiver (WR) | Tight end (TE) | Quarterback (QB)