The game will feature a new-look Liverpool side where blockbuster goalkeeper signing Alisson is set to make his debut for the side , along with recent arrivals Naby Keita, Fabinho and Xherdan Shaqiri.
Napoli, meanwhile, will prepare for the new season with new manager Carlo Ancelotti after Maurizio Sarri left in the summer to coach Chelsea.
Here is everything you need to know about Saturday's friendly.
|Game||Liverpool vs Napoli|
|Date||Saturday, August 4|
|Time||6pm BST / 1pm ET|
TV Channel, Live Stream & How To Watch
In the United States (US), the game will be shown on Eleven Sports network and livestreamed on LFC TV.
|US TV channel||Online stream|
|Eleven Sports||LFC TV|
In the United Kingdom (UK), the game can be watched live on LFC TV on streamed live online on LFC TV.
|UK TV channel||Online stream|
|LFC TV||LFC TV|
Squads & Team News
|Goalkeepers||Alisson, Karius, Kelleher|
|Defenders||Clyne, Gomez, Van Dijk, Moreno, Alexander-Arnold, Robertson, Klavan|
|Midfielders||Jones, Fabinho, Milner, Keita, Shaqiri, Wijnaldum, Markovic|
|Forwards||Sturridge, Firmino, Mane, Salah, Solanke|
Nathaniel Clyne is once again available for the clash after leaving the U.S. tour early due to the birth of his new baby.
However, Naby Keita was still nursing a neck problem for the last two fixtures in the U.S. and may be sidelined as a precaution, while Roberto Firmino may also be rested after he joined up with the team for the first time on Monday.
Adam Lallana, Joel Matip, Marko Grujic and Danny Ings will all miss out on the friendly due to injury precautions.
Potential Liverpool XI: Alisson; Clyne, Gomez, van Dijk, Robertson; Milner, Fabinho, Shaqiri; Salah, Sturridge, Mane.
|Defenders||Albiol, Chiriches, Ghoulam, Koulibaly, Maksimovic, Mario Rui, Tonelli|
|Midfielders||Allan, Diawara, Fabian, Hamsik, Rog, Zielinski|
|Forwards||Callejon, Inglese, Insigne, Mertens, Ounas, Verdi|
Napoli will be the fresher-looking side following Liverpool's involvement in the ICC in the United States, and also have the benefits of selecting from a full-strength squad.
Potential Napoli XI: Karnezis; Hysaj, Albiol, Koulibaly, Rui; Allan, Ruiz; Insigne, Hamsik, Verdi; Milik.
Betting & Match Odds
Liverpool are priced at odds of winning 4/1 according to dabblebet , while a draw is available at 2/1. A win for Napoli is priced at 15/8.
Liverpool have been preparing for the friendly clash against Napoli with a week-long intensive training camp in Evian, France following their pre-season tour around the United States where they faced the likes of Borussia Dortmund, Manchester City and Manchester United.
The Reds head into the fixture in Dublin fresh off a triumphant 4-1 pounding of rivals United in Michigan, with the likes of Sadio Mane and Mohamed Salah already looking sharp despite joining up with the squad in late July following their post-World Cup holiday.
New signing Alisson could also be handed his first start for the Reds after signing for the club in a world-record fee of £67m for a goalkeeper.
Roberto Firmino may be rested for the game ahead of Liverpool's final pre-season friendly against Torino on Tuesday after getting his pre-season preparations underway earlier this week.
Trent Alexander-Arnold opted to end his holiday early to return to Liverpool earlier, while Jurgen Klopp has also been handed a squad boost in the form of a rejuvenated Daniel Sturridge , who has already scored four goals in pre-season following a lacklustre loan move to West Brom.
Carlo Ancelotti will be eager to challenge for the top honours once again this season with his new side and will be relying on the skilled, attack-minded likes of Dries Mertens, Jose Callejon and Lorenzo Insigne.