Simeone has one year left on his contract with the Liga club and his future remains uncertain beyond 2018.
"I would never close the door on any job because I like to work, I like football. And football is not just in Europe, it is not just in one club, so I always keep an open mind," Simeone said following Atletico's preseason 0-0 draw against Liga MX side Deportivo Toluca.
"I would never close the door on coaching in Mexico. Football is not just in Europe, there is football all over the world so I am always open to the idea of managing anywhere in the world.
"Liga MX is a great environment, the fans are very enthusiastic. They participate the entire time and they support their team and for our first match we think it went well.
"It isn't easy to play at this altitude and I think we handled it well."
Alteltico opened its pre-season friendlies at 8,750 feet above sea level in Toluca, following an intense training camp at Los Angeles de San Rafael.