The Spain striker sustained a hamstring injury in the club's 1-0 defeat to Manchester City before the October international break and missed out on Chelsea's shock loss to Crystal Palace last weekend.
Michy Batshuayi, who started the Palace match, drops to the bench to make way for Morata. Willian and Victor Moses also drop to the bench with the latter out for around a month due to a hamstring injury he sustained in the last match.
Chelsea are switching formation to a 3-5-2 with David Luiz moving into midfield. N'Golo Kante's absence through injury was hard felt at Selhurst Park and Antonio Conte will hope that Luiz can provide the midfield with more resiliance.
Andreas Christensen returns to the line up for the three man defence.
Chelsea XI: Courtois, Azpilicueta, Christensen, Cahill (c); David Luiz, Zappacosta, Bakayoko, Fabregas, Alonso; Hazard; Morata.