Lionel Messi and Luis Suarez line up against the trident of Mohammed Salah, Sadio Mane and Roberto Firmino in a game which sees two of Europe's best attacking sides go head to head for a place in the Champions League final.
Messi boasts a sensational record against English opposition having netted 24 goals in 32 games against sides from the Premier League, yet the Argentine failed to score in his two previous games against the Anfield outfit.
Latest odds
Messi is the tournament's top scorer this season with 10 goals, two of which came in his side's last home game against Manchester United.
The five-time Ballon d'Or winner is priced at 5/2 (3.50) with William Hill to break the deadlock as he did against United and just 7/10 (1.70) to score at any time.
Suarez faces his former side for the first time since leaving Merseyside and while the Uruguayan has scored 21 times in La Liga this term, he is yet to find the back of the net in Europe.
The striker is priced at 21/20 (2.05) to score what would be his first Champions League goal in over a year and at 33/1 (34.00) for a first ever Champions League hat-trick.
Reds to cause problems
The Spanish champions will be wary of Liverpool's firepower, with the speed and directness of the Premier League side capable of unsettling Barcelona.
Salah, Mane and Firmino have all scored in the same game on two occasions in this season's Champions League and while that feat is unlikely to be repeated on Wednesday, it is probable that one of the three will find the back of the net.
The trio have four goals apiece in the Champions League, while Salah is the Reds' top scorer in all competitions with 25 goals ahead of Mane with 24 and Firmino on 16.
Tips and predictions
Firmino is offered at 13/5 (3.60) to score at anytime with Salah and Mane both priced at 15/8 (2.87). In truth there is little to pick between them, yet of the three backing Mane to net perhaps makes most sense.
Three of his four goals in the competition have come in the knockout stages, while last season he was prolific from the last 16 onwards - netting seven times including in the final.
Sadio Mane to score at anytime at 15/8 (2.87) for a 1p.5t stake with William Hill
William Hill