Thuram was last in action when he helped Inter overcome Bayern Munich in the Champions League quarter-finals on Wednesday night. He played the full game as his side set up a semi-final with Barcelona, but his participation against the La Liga giants has been thrown into doubt after his side confirmed he is struggling with muscle fatigue in his left thigh.
Sky Italia claim the Frenchman is likely to be rested this weekend and could also miss the second leg of their Coppa Italia semi-final against AC Milan, but he could be available to take on Roma before the first outing with Barca.