The pair were injured while on international duty with England and looked set to be last-minute fitness decisions, but on Friday afternoon the City boss ruled both out of contention for the Etihad clash.
In brighter news for the Spaniard, Jack Grealish was back on the training ground and looks set to be available for the first time in a month. And there was a further encouraging development as Ederson also trained with team-mates and is in contention to make a quicker-than-anticipated recovery from the thigh injury he suffered against Liverpool earlier this month. Meanwhile, Kevin De Bruyne has received a clean bill of health after skipping international duty with Belgium with a groin issue.