Wrexham had early sights of goal through Jack Marriott and Sam Dalby before opening the scoring midway through the first half. Luke Young swung in a superb corner and found James McClean to nod home at the near post. The lead was short-lived, however, with Dan Kemp firing past Arthur Okonkwo just five minutes later to make it 1-1.
The visitors were bright at the start of the second half but almost conceded when Okonkwo dropped a straightforward catch but just managed to grab it back on the line. MK Dons felt the ball had dropped in with Dean Lewington ultimately sent off for taking his protests too far.
Phil Parkinson reacted quickly to the dismissal with a triple substitution, calling for strikers Paul Mullin and Steven Fletcher, but his team couldn't take their chances. The visitors were then reduced to ten men late on when Will Boyle picked up a second yellow card. MK Dons did have the chance to win it at the death, but Okonkwo made a point-blank save in the eighth minute of stoppage-time to preserve a point.