Luke Shaw will also have his chance to shine having been selected by Jose Mourinho in the left-back role, and skipper Wayne Rooney returns in place of the rested Henrikh Mkhitaryan after missing out on selection in Thursday's Manchester derby.
Juan Mata is back in the matchday squad among the substitutes after recovering from groin surgery, while youngster Axel Tuanzebe is joined on the bench by Under-23 team-mate Scott McTominay.
McTominay is a utility midfielder who has played much of his football under Nicky Butt this season either as a No.10 or a fill-in striker.
Man Utd: De Gea, Bailly, Rooney, Martial, Lingard, Carrick, Blind, Young, Rashford, Herrera, Shaw. Subs: Mata, Romero, Mkhitaryan, Valencia, Darmian, Tuanzebe, McTominay.
Swansea: Fabianski, Ayew, Ki, Mawson, Britton, Llorente, Sigurdsson, Naughton, Fernandez, Kingsley, Carroll. Subs: Amat, Fer, Borja Gonzalez, Nordfeldt, Olsson, Montero, Cork.