The San Francisco 49ers (1-0) hit the road this weekend, heading into the Caesars Superdome for a Sunday showdown with the New Orleans Saints (0-1).
San Francisco comes in riding some early momentum after grinding out a 17-13 win over NFC West rival Seattle in Week 1. The Niners’ defense proved to be the difference, standing tall late to seal the victory. Still, Kyle Shanahan’s team has dropped seven of its last nine overall, making this a key opportunity to steady the ship before upcoming matchups against the Cardinals and Jaguars.
On the other side, New Orleans is trying to stop the bleeding after dropping its fifth straight contest. The Saints opened their season with a frustrating 20-13 home loss to the Arizona Cardinals, leaving Dennis Allen’s group searching for answers before dates with the Seahawks and Bills.
| Date | Sunday, September 14, 2025 |
| Time | 1:00 pm ET / 12:00 pm CT/ 10:00 am PT |
| Venue | Caesars Superdome (New Orleans, Louisiana) |
| TV Channel | FOX |
| Streaming | Fubo (Try for free) |
| Buy Tickets | Stubhub |
| Odds | 49ers -225 | Saints +185 |
New Orleans Saints vs San Francisco 49ers roster & injury news
New Orleans Saints team news
Quarterback Spencer Rattler managed 214 passing yards on 58.7 percent completions in the opener, though he’s still waiting on his first touchdown toss of the season. Juwan Johnson and Chris Olave led the aerial attack with 15 combined grabs for 130 yards, while Rashid Shaheed added six catches of his own.
On the ground, Alvin Kamara paced the rushing unit with 45 yards and a score, helping New Orleans average 107 rushing yards per outing. Defensively, the Saints have surrendered 20 points and 276 yards per game so far, with linebacker Pete Werner posting a team-best nine tackles, Cameron Jordan notching 1.5 sacks, and Carl Granderson breaking up two passes.
Saints Injury Report : Chase Young, DE - Questionable , Trevor Penning, OT - Questionable , Jordan Howden, S - Questionable , Julian Blackmon, S - Questionable , Taliese Guaga, OT - Questionable
| Position | Players |
|---|---|
| Offense | Spencer Rattler, Tyler Shough (QB); Velus Jones Jr., Alvin Kamara, Kendre Miller, Devin Neal (RB); Brandin Cooks, Chris Olave, Trey Palmer, Rashid Shaheed, Mason Tipton, Devaughn Vele (WR); Juwan Johnson, Moliki Matavao (TE); Luke Fortner, Erik McCoy, Cesar Ruiz (C); Torricelli Simpkins III (G); Kelvin Banks Jr., Taliese Fuaga, Trevor Penning, Dillon Radunz, Asim Richards, Xavier Truss (OT) |
| Defense | Jonathan Bullard, Carl Granderson, Cameron Jordan, Chris Rumph II, Chase Young (DE); Khristian Boyd, Bryan Bresee, Vernon Broughton, Davon Godchaux, Nathan Shepherd (DT); Demario Davis, Jaylan Ford, Isaiah Stalbird, Danny Stutsman, Pete Werner (LB); Kool-Aid McKinstry, Quincy Riley, Alontae Taylor, Rejzohn Wright, Isaac Yiadom (CB); Ugo Amadi, Julian Blackmon, J.T. Gray, Jordan Howden, Justin Reid, Jonas Sanker (S) |
| Special Teams | Blake Grupe (PK), Kai Kroeger (P), Zach Wood (LS) |
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San Francisco 49ers team news
For the 49ers, Brock Purdy picked up right where he left off last season, completing 74.3 percent of his throws for 277 yards with two touchdowns, though he also tossed a pair of interceptions. Ricky Pearsall and Christian McCaffrey combined for 181 yards on 13 receptions, while fullback Kyle Juszczyk chipped in a couple of grabs. On the ground, McCaffrey shouldered the load with 22 carries for 69 yards, part of a rushing attack averaging 119 yards per game.
Defensively, San Francisco looks sharp once again, holding opponents to just 13 points and 230 total yards per contest. Fred Warner leads the charge with eight tackles, Nick Bosa already has one sack to his name, and Upton Stout added a pass breakup.
49ers Injury Report : George Kittle, TE - Out , Jauan Jennings, WR - Questionable , Jordan Watkins, WR - Questionable , Jordan James, RB - Questionable , Brock Purdy, QB - Questionable
| Position | Players |
|---|---|
| Offense | Mac Jones, Brock Purdy (QB); Isaac Guerendo, Jordan James, Christian McCaffrey, Brian Robinson Jr. (RB); Kyle Juszczyk (FB); Jauan Jennings, Skyy Moore, Ricky Pearsall, Demarcus Robinson, Jordan Watkins (WR); Luke Farrell, George Kittle, Jake Tonges (TE); Jake Brendel, Matt Hennessy (C); Ben Bartch, Connor Colby, Drew Moss, Dominick Puni (G); Isaac Alarcon, Spencer Burford, Colton McKivitz, Austen Pleasants, Trent Williams (OT) |
| Defense | Robert Beal Jr., Nick Bosa, Yetur Gross-Matos, Bryce Huff, Mykel Williams (DE); Alfred Collins, Kalia Davis, Jordan Elliott, Jordan Jefferson, Sam Okuayinonu, CJ West (DT); Tatum Bethune, Luke Gifford, Nick Martin, Fred Warner, Dee Winters (LB); Renardo Green, Deommodore Lenoir, Chase Lucas, Darrell Luter Jr., Siran Neal, Upton Stout (CB); Ji'Ayir Brown, Jason Pinnock, Marques Sigle (S) |
| Special Teams | Jake Moody (PK); Thomas Morstead (P); Jon Weeks (LS) |
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New Orleans Saints vs San Francisco 49ers head-to-head record
The long-running Saints–49ers series has featured 79 contests overall, including one postseason clash, with San Francisco owning a 50–27 edge and two meetings ending in a draw.
Watch and live stream Saints vs 49ers in the USA
The New Orleans Saints vs the San Francisco 49ers game in Week 2 of the 2025 NFL season will be broadcast live nationally on FOX. Fans will be able to catch the coverage onFubo (Try for free today!).
More details on where to watch the game in the United States, including streaming options, will be released soon, so keep an eye out for our dedicated coverage.
Watch and live stream Saints vs 49ers worldwide
For fans outside the U.S. looking to stay plugged into the action,NFL Game Pass on DAZN is the ultimate ticket. It serves up more than 200 regular-season and playoff matchups, complete Super Bowl coverage, plus access to NFL Network, NFL RedZone, and plenty more to keep you locked in all year long.
To bypass regional restrictions or to access the game if you are travelling abroad, you can watch the action using a Virtual Private Network like ExpressVPN.
How to buy Saints vs 49ers tickets
The showdown between the Saints and 49ers is set for Caesars Superdome in New Orleans, Louisiana, a venue that packs in up to 83,000 fans and promises a fiery atmosphere on game day.
Tickets are already up for grabs on StubHub, with entry starting at $386. From there, prices climb through the tiers — $300, $400, $500, $600, $700, $800, $900, $1,000, and stretching all the way into the premium ranges of $2,000, $3,000, $4,000, $5,000, $6,000, and topping out at $10,406 for the best seats in the house.
Check the link below for the full breakdown of how to purchase tickets to NFL games.
READ MORE: NFL 2025 Tickets: Prices, deals, season tickets & membership information
Saints vs 49ers Fantasy Football
For fantasy football, 49ers RB Christian McCaffrey is a must-start RB1, projected for 21.8 points even against a Saints defense known for run-stopping. With TE George Kittle on IR, Ricky Pearsall emerges as a clear WR3 option after a strong Week 1 showing, while Jauan Jennings offers upside as a flex if healthy, though he carries added risk with Brock Purdy out. Backup QB Mac Jones slots in at QB27, expected to deliver modest production versus New Orleans.
For the Saints, RB Alvin Kamara is a low-end RB2/flex option, but his matchup against San Francisco’s stout run defense limits ceiling. WRs Chris Olave and Rashid Shaheed have WR3/flex appeal, though they’re tethered to a shaky passing game led by QB Spencer Rattler (QB28 this week). TE Juwan Johnson is a boom-or-bust TE14, primarily a red-zone target but inconsistent from week to week.
Fantasy Takeaways:
- Lock in 49ers RB Christian McCaffrey as an elite RB1.
- Start 49ers WR Ricky Pearsall as a reliable WR3; Jauan Jennings as a high-upside, higher-risk flex.
- Use Saints RB Alvin Kamara as a moderate-upside flex option.
- Target Saints WR Chris Olave and Rashid Shaheed cautiously due to QB uncertainty.
- Start 49ers QB Mac Jones with tempered expectations.
- Both team defenses are fantasy-average, with San Francisco D/ST slightly favored.
Saints vs 49ers Game Predictions
Looking ahead to Sunday, oddsmakers give the 49ers a 64.9% chance of victory, while New Orleans carries just a 34.9% probability, with the sliver left over accounting for the rare possibility of a tie.
Even with a few key players still working back to full strength, San Francisco looks formidable. The return of star back Christian McCaffrey and defensive guru Robert Saleh provides a major boost. Head coach Kyle Shanahan should relish this matchup: Saints defensive coordinator Brandon Staley’s schemes have often left soft spots for opponents to exploit on the ground.
New Orleans’ youthful offensive front might manage to keep the Niners’ pass rush from completely taking over, but expect McCaffrey and quarterback Brock Purdy to control time of possession and dictate the pace. With that recipe, San Francisco is well positioned to leave the Superdome with a convincing Week 2 win.
Saints vs 49ers Betting Odds
Spread
49ers -4.5 (-110) | Saints +4.5 (-110)
Moneyline
49ers -225 | Saints +185
Total
OVER 42.5 (-110) | UNDER 42.5 (-110)
More NFL news and coverage
- Saints 2025 NFL schedule: TV channel, livestream & where to watch the games
- 49ers 2025 NFL schedule: TV channel, livestream & where to watch the games
- How to watch and live stream NFL football for free and without cable
- 2025 fantasy football rankings: Running back (RB) | Wide receiver (WR) | Tight end (TE) | Quarterback (QB)