Southampton kick off their 2021-22 Premier League season with an away fixture against Everton before a tough test against Manchester United in gameweek two.
A tricky run of fixtures towards the end of January and at the beginning of February, meanwhile, sees Ralph Hasenhuttl's side face Manchester City, Tottenham and Manchester United in consecutive matches.
Indeed, Southampton were beaten 9-0 by United at Old Trafford back in February 2021 and will be hoping to put on a much better show against Ole Gunnar Solskjaer's men a year later.
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The two matches against Brighton, meanwhile, will take place on December 4, at St Mary's Stadium, and April 23, at the Amex.
The Saints' penultimate game of the Premier League season is a tricky home fixture against Jurgen Klopp's Liverpool, although they did manage to beat the Merseysiders 1-0 in the same fixture in the 2020-21 season.
Southampton end their campaign away at Leicester City on May 22 and they'll undoubtedly be looking for an improvement on their 15th-placed finish from last season.
Southampton Premier League fixtures 2021-22
|14/08/2021||15:00||Everton v Southampton|
|21/08/2021||15:00||Southampton v Manchester United|
|28/08/2021||15:00||Newcastle United v Southampton|
|11/09/2021||15:00||Southampton v West Ham United|
|18/09/2021||15:00||Manchester City v Southampton|
|25/09/2021||15:00||Southampton v Wolverhampton|
|02/10/2021||15:00||Chelsea v Southampton|
|16/10/2021||15:00||Southampton v Leeds United|
|23/10/2021||15:00||Southampton v Burnley|
|30/10/2021||15:00||Watford v Southampton|
|06/11/2021||15:00||Southampton v Aston Villa|
|20/11/2021||15:00||Norwich City v Southampton|
|27/11/2021||15:00||Liverpool v Southampton|
|01/12/2021||19:45||Southampton v Leicester City|
|04/12/2021||15:00||Southampton v Brighton|
|11/12/2021||15:00||Arsenal v Southampton|
|14/12/2021||20:00||Crystal Palace v Southampton|
|18/12/2021||15:00||Southampton v Brentford|
|26/12/2021||15:00||West Ham United v Southampton|
|28/12/2021||15:00||Southampton v Tottenham Hotspur|
|01/01/2022||15:00||Southampton v Newcastle United|
|15/01/2022||15:00||Wolverhampton v Southampton|
|22/01/2022||15:00||Southampton v Manchester City|
|09/02/2022||19:45||Tottenham Hotspur v Southampton|
|12/02/2022||15:00||Manchester United v Southampton|
|19/02/2022||15:00||Southampton v Everton|
|26/02/2022||15:00||Southampton v Norwich City|
|05/03/2022||15:00||Aston Villa v Southampton|
|12/03/2022||15:00||Southampton v Watford|
|19/03/2022||15:00||Burnley v Southampton|
|02/04/2022||15:00||Leeds United v Southampton|
|09/04/2022||15:00||Southampton v Chelsea|
|16/04/2022||15:00||Southampton v Arsenal|
|23/04/2022||15:00||Brighton v Southampton|
|30/04/2022||15:00||Southampton v Crystal Palace|
|07/05/2022||15:00||Brentford v Southampton|
|15/05/2022||15:00||Southampton v Liverpool|
|22/05/2022||16:00||Leicester City v Southampton|