The Arizona Cardinals (0-0) head to Caesars Superdome on Sunday to square off with the New Orleans Saints (0-0), with kickoff set for 1:00 p.m. EDT in New Orleans.
Expectations couldn’t be more different for these two squads. New Orleans enters the season with one of the league’s lowest projected win totals and has committed to Spencer Rattler under center after he edged rookie Tyler Shough, despite Rattler’s 0-6 record in 2025.
Meanwhile, Arizona is eyeing a bounce-back year after stumbling to an 8-9 finish last season. With the NFC West looking fairly open, the Cardinals have a legitimate shot at competing for the division crown—but only if Kyler Murray can deliver consistently from Week 1 through Week 18, rather than fading after a strong start.
| Date | Sunday, September 7, 2025 |
| Time | 1:00 pm ET / 12:00 pm CT/ 10:00 am PT |
| Venue | Caesars Superdome (New Orleans, Louisiana) |
| TV Channel | CBS |
| Streaming | Fubo |
| Buy Tickets | Stubhub |
| Odds | +230 (Saints) | -285 (Cardinals) |
New Orleans Saints vs Arizona Cardinals roster & injury news
New Orleans Saints team news
Spencer Rattler will take the reins of the Saints’ offense in Week 1 after edging out rookie Tyler Shough in the quarterback competition. The second-year signal-caller is expected to lean heavily on his top playmakers, turning to star receiver Chris Olave and versatile veteran Alvin Kamara as he looks to guide New Orleans to an opening-day victory.
| Position | Players |
|---|---|
| Offense | Spencer Rattler, Tyler Shough (QB); Velus Jones Jr., Alvin Kamara, Kendre Miller, Devin Neal (RB); Brandin Cooks, Chris Olave, Trey Palmer, Rashid Shaheed, Mason Tipton, Devaughn Vele (WR); Juwan Johnson, Moliki Matavao (TE); Luke Fortner, Erik McCoy, Cesar Ruiz (C); Torricelli Simpkins III (G); Kelvin Banks Jr., Taliese Fuaga, Trevor Penning, Dillon Radunz, Asim Richards, Xavier Truss (OT) |
| Defense | Jonathan Bullard, Carl Granderson, Cameron Jordan, Chris Rumph II, Chase Young (DE); Khristian Boyd, Bryan Bresee, Vernon Broughton, Davon Godchaux, Nathan Shepherd (DT); Demario Davis, Jaylan Ford, Isaiah Stalbird, Danny Stutsman, Pete Werner (LB); Kool-Aid McKinstry, Quincy Riley, Alontae Taylor, Rejzohn Wright, Isaac Yiadom (CB); Ugo Amadi, Julian Blackmon, J.T. Gray, Jordan Howden, Justin Reid, Jonas Sanker (S) |
| Special Teams | Blake Grupe (PK), Kai Kroeger (P), Zach Wood (LS) |
Arizona Cardinals team news
On the other side, Arizona’s offense will be driven by the electrifying Kyler Murray, whose dual-threat ability gives the Cardinals plenty of upside. Murray has an impressive supporting cast at his disposal, highlighted by sophomore standout Marvin Harrison Jr., hard-nosed runner James Conner, and emerging tight end Trey McBride, already regarded as one of the brightest young talents at his position.
| Position | Players |
|---|---|
| Offense | Jacoby Brissett, Kyler Murray (QB); Trey Benson, James Conner, Emari Demercado, Bam Knight (RB); Greg Dortch, Marvin Harrison Jr., Zay Jones, Xavier Weaver, Michael Wilson (WR); Elijah Higgins, Trey McBride, Tip Reiman, Travis Vokolek (TE); Evan Brown (C); Isaiah Adams, Hjalte Froholdt, Jon Gaines II, Will Hernandez (G); Kelvin Beachum, Josh Fryar, Paris Johnson Jr., Jonah Williams (OT) |
| Defense | L.J. Collier, Darius Robinson (DE); Calais Campbell, PJ Mustipher, Dante Stills, Dalvin Tomlinson (DT); Baron Browning, Jordan Burch, Zaven Collins, Akeem Davis-Gaither, Owen Pappoe, Cody Simon, Josh Sweat, Xavier Thomas, Mack Wilson Sr. (LB); Denzel Burke, Kei'Trel Clark, Will Johnson, Elijah Jones, Max Melton, Garrett Williams (CB); Budda Baker, Joey Blount, Kitan Crawford, Dadrion Taylor-Demerson, Jalen Thompson (S) |
| Special Teams | Chad Ryland (PK), Blake Gillikin (P), Aaron Brewer (LS) |
Saints vs Cardinals head-to-head record
As for history, the Saints and Cardinals are as evenly matched as it gets, the series stands tied at 16-16 through 32 meetings, including one playoff clash.
Which channel is Saints vs Cardinals game on?
The New Orleans Saints vs Arizona Cardinals game in Week 1 of the 2025 NFL season will air live on CBS in the US. Fans will be able to catch the coverage onFubo (Try for free today!).
More details on where to watch the game in the United States, including streaming options, will be released soon, so keep an eye out for our dedicated coverage.
For fans outside the U.S. looking to stay plugged into the action,NFL Game Pass on DAZN is the ultimate ticket. It serves up more than 200 regular-season and playoff matchups, complete Super Bowl coverage, plus access to NFL Network, NFL RedZone, and plenty more to keep you locked in all year long.
How to buy Saints vs Cardinals ticket
Tickets are already up for grabs on StubHub, with entry starting at $386. From there, prices climb through the tiers — $300, $400, $500, $600, $700, $800, $900, $1,000, and stretching all the way into the premium ranges of $2,000, $3,000, $4,000, $5,000, $6,000, and topping out at $10,406 for the best seats in the house.
Check the link below for the full breakdown of how to purchase tickets to NFL games.
READ MORE: NFL 2025 Tickets: Prices, deals, season tickets & membership information
Saints vs Cardinals Fantasy Football
Fantasy managers should lean heavily toward Arizona’s playmakers this week, with the Cardinals entering as favorites and boasting the more well-rounded roster. Kyler Murray looks primed for a big opener, with projections pointing to three touchdown passes. His dual-threat ability and a scheme tailored for fireworks make him a strong QB start. Rookie star Marvin Harrison Jr. is expected to emerge as the top red-zone target despite some early chemistry concerns with Murray — the Cardinals believe they’ve ironed those wrinkles out. Add in Arizona’s upgraded defense and special teams, which could chip in fantasy points of their own, and this unit has plenty of appeal.
For the Saints, it’s all about Alvin Kamara, who remains the engine of their offense and is pegged for both of New Orleans’ touchdowns in Week 1. His workload and red-zone usage make him a must-start despite the ongoing questions about his mileage. Meanwhile, James Conner draws a favorable matchup against a Saints defense that’s shown cracks against the run, giving him solid RB value. Beyond that, however, the Saints’ new-look attack under rookie head coach Kellen Moore could take some time to gel, so it’s wise to tread carefully with other New Orleans skill players until their rhythm settles.
Fantasy lineup takeaways:
- Lock in Kyler Murray (19.2 fpts for Week 1) and Marvin Harrison Jr. (15.2 fpts for Week 1) from the Cardinals.
- Alvin Kamara (15.5 fpts for Week 1) is the top Saints fantasy option.
- James Conner is a strong Week 1 RB start with upside.
- Take a wait-and-see approach on the rest of New Orleans’ offense until consistency kicks in.
Saints vs Cardinals Game Predictions
Spencer Rattler delivers a few flashes that get the home crowd buzzing, and Alvin Kamara manages to slip into space against Arizona’s revamped linebacker corps. Still, New Orleans’ attack struggles to keep pace with the Cardinals’ offensive punch.
The combination of Kyler Murray, Marvin Harrison Jr., and Trey McBride overwhelms the Saints’ secondary, with Arizona piling on the points in convincing fashion.
The Arizona Cardinals head into Sunday’s opener as slight favorites, carrying a 57% probability of coming out on top. The Saints aren’t far behind, though, with oddsmakers giving them a 42.7% chance to steal the win, while the slim remainder leaves room for the rare possibility of a tie.
Saints vs Cardinals Odds
Spread: Saints +6.5 (-110), Cardinals -6.5 (-110)
Total: 42.5 (Over -112/Under -108)
Moneyline: +230 (Saints) | -285 (Cardinals)
More NFL news and coverage
- Saints 2025 NFL schedule: TV channel, livestream & where to watch the games
- Cardinals 2025 NFL schedule: TV channel, livestream & where to watch the games
- How to watch and live stream NFL football for free and without cable
- 2025 fantasy football rankings: Running back (RB) | Wide receiver (WR) | Tight end (TE) | Quarterback (QB)