The Gunners boss broke the mark set by Sir Alex Ferguson when he led the Gunners in Sunday's match at West Bromwich Albion.
Wenger began his two-decade run in north London in 1996, and has led Arsenal to three Premier League titles along with seven FA Cups.
811 - Arsene Wenger is set to manage his 811th Premier League game - overtaking Sir Alex Ferguson, whose 810th and final match in the competition also took place at the Hawthorns. Cycle. pic.twitter.com/YFlLVl3AvI— OptaJoe (@OptaJoe) December 31, 2017
In his 810 league matches at the helm, Wenger has compiled a record of 468 wins, 197 draws and 145 losses.
Though Wenger has bested Ferguson's Premier League mark, the Scottish manager has still taken charge of far more top-flight matches in England.
Ferguson managed 223 First Division matches from 1986 to the advent of the Premier League in 1992, giving him a total of 1,033 in the English top flight.