It appeared Kyle Walker indicated to the coaching staff that someone had sustained a calf injury, before Kompany was forced off.
Walker’s passed on a message to the bench, sounds like somebody’s got a calf problem. Kompany?— Sam Lee (@Sammy_Goal) December 27, 2017
The 31-year-old defender tried to play through the injury for a time before being replaced by Gabriel Jesus. Fernandinho moved from the midfield to centre-back to take Kompany's place on the back line.
The Citizens are already missing Kompany's regular partner, as John Stones has been sidelined since November 18 with a hamstring injury. Nicolas Otamendi has filled in as a replacement while Stones nears a return.
Kompany punches the dug-out as he takes his seat — Sam Lee (@Sammy_Goal) December 27, 2017
Assorted injuries have limited Kompany over the last few seasons as he was limited to just 27 Premier League appearances the past two campaigns. This season he has only featured in eight Premier League contests for Manchester City and has not appeared in the Champions League this season.
The injury which sidelined Kompany for much of this season was also a calf injury, but it is not clear if this is a re-occurrence of that problem.