The United boss already hinted in his pre-match press conference that Shaw was likely to get some minutes and the former Southampton ace starts alongside Antonio Valencia, Chris Smalling and Victor Lindelog at the back.
Sergio Romero, meanwhile, has gotten the nod between the sticks as David de Gea is rested before Sunday's derby against Manchester City.
Daley Blind and Ander Herrera get a chance to prove their worth as United's holding midfielders, while Marcus Rashford and Juan Mata flank Pogba in a more attacking role.
Romelu Lukaku starts up front as Anthony Martial has to settle for a spot on the bench, with Zlatan Ibrahimovic not in the squad.
Ashley Young gets to watch on from the bench with an eye on the derby against City, while Jesse Lingard has also been rested after his stellar performance against Arsenal at the weekend.
Man Utd starting XI: Romero, Valencia(c), Lindelof, Smalling, Blind, Shaw, Herrera, Pogba, Mata, Rashford, Lukaku
Subs: Pereira, Darmian, Tuanzebe, Young, McTominay, Lingard, Martial