Son's strike was his 20th in a Tottenham shirt, lifting him above countryman Park Ji-Sung, who scored 19 English top-flight goals while at Manchester United, in the Asian goalscoring charts.
"It was a very important win," Son told Spurs' official website. "I'm very happy to break the record. My family were here and it's a special day for me."
Swansea's Ki Sung-yueng, also a South Korea international, is third in the rankings with 13, with Leicester City's Shinji Okazaki in fouth with 12 goals in 75 appearances for the Foxes.
|Son Heung-Min||Korea Republic||20||72|
|Park Ji-Sung||Korea Republic||19||154|
|Ki Sung-yueng||Korea Republic||13||145|
|Lee Chung-yong||Korea Republic||8||100|
|Seol Ki-Hyeon||Korea Republic||5||48|
Crystal Palace's Lee Chung-yong completes the top five with eight goals in 100 Premier League appearances.
Former Japan international Junichi Inamoto's four goals for Fulham ranks him just inside the top 10.