The first two matches under the new manager were hugely impressive last month, with La Roja beating England 2-1 at Wembley and thrashing World Cup finalists Croatia by a 6-0 scoreline.
Thursday's friendly in Cardiff is a chance for Spain to continue that excellent form and it could be a tough evening for a Wales side likely to be without Gareth Bale.
Bale joined up with his country despite seemingly picking up a knock in Real Madrid's game on Saturday night, and the forward is unlikely to be risked in a friendly ahead of a Nations League clash against the Republic of Ireland.
Spain have Isco missing as he recovers from appendicitis, while Dani Carvajal, Sergi Roberto and Diego Costa are all out injured.
Spain have been a bit more direct and aggressive under Luis Enrique, and the two matches of his tenure have been hugely encouraging for fans.
La Roja's exit from the World Cup underlined that having large swathes of possession is useless unless it is used creatively, and Enrique will aim to move the ball quickly and have runners moving intelligently into space.
Wales are likely to sit back against them and this should be a good test to see if the new manager can find a system to break down highly defensive opponents.
Tips and predictions
The latter looks like a great option, despite the probable defensive set up from Wales. The Welsh have considerably less quality than Spain and if they get into their stride as they did against Croatia last month, La Roja will be tough to stop.
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