The pair began City's 2-2 draw against Middlesbrough on the bench last week, but Pep Guardiola has returned them to the first XI for the Palace clash.
The Catalan coach has also decided to use Fernandinho in a right-back berth once again, while his fellow Brazilian Gabriel Jesus leads the line up front.
Sergio Aguero, John Stones and Claudio Bravo are all nursing knocks and miss out as a result.
Man City team: Caballero, Fernandinho, Kompany (c), Otamendi, Clichy, Yaya Toure, Sterling, De Bruyne, Silva, Sane, Gabriel Jesus. Subs: Gunn, Sagna, Zabaleta, Fernando, Kolarov, Navas, Iheanacho.
Crystal Palace team: Hennessey, Ward, Kelly, van Aanholt, Schlupp, Milivojevic, Puncheon, McArthur, Zaha, Townsend, Benteke. Subs: Speroni, Delaney, Flamini, Lee, Sako, Remy, Campbell.