Pep Guardiola's side will then take on Bournemouth at home before facing off against Newcastle at St. James' Park.
City successfully defended their Premier League crown last season and will hoping to get the new campaign off to a positive start as they aim to secure a third straight title, and fifth in six years.
GOAL brings you Man City's full Premier League fixture list for 2022-23, key dates and ticket details for those wishing to go to games.
Man City Premier League 2022-23 fixture list
Fixtures are subject to change pending TV schedules and events.
|07/08/2022||16:30||West Ham United v Manchester City|
|13/08/2022||15:00||Manchester City v A.F.C. Bournemouth|
|21/08/2022||16:30 (Sky Sports)||Newcastle United v Manchester City|
|27/08/2022||15:00||Manchester City v Crystal Palace|
|31/08/2022||19:30 (BT Sport)||Manchester City v Nottingham Forest|
|03/09/2022||17:30 (Sky Sports)||Aston Villa v Manchester City|
|10/09/2022||17:30 (Sky Sports)||Manchester City v Tottenham Hotspur|
|17/09/2022||12:30 (BT Sport)||Wolverhampton v Manchester City|
|01/10/2022||15:00||Manchester City v Manchester United|
|08/10/2022||15:00||Manchester City v Southampton|
|15/10/2022||15:00||Liverpool v Manchester City|
|18/10/2022||19:45||Arsenal v Manchester City|
|22/10/2022||15:00||Manchester City v Brighton|
|29/10/2022||15:00||Leicester City v Manchester City|
|05/11/2022||15:00||Manchester City v Fulham|
|12/11/2022||15:00||Manchester City v Brentford|
|26/12/2022||15:00||Leeds United v Manchester City|
|31/12/2022||15:00||Manchester City v Everton|
|02/01/2023||15:00||Chelsea v Manchester City|
|14/01/2023||15:00||Manchester United v Manchester City|
|21/01/2023||15:00||Manchester City v Wolverhampton|
|04/02/2023||15:00||Tottenham Hotspur v Manchester City|
|11/02/2023||15:00||Manchester City v Aston Villa|
|18/02/2023||15:00||Nottingham Forest v Manchester City|
|25/02/2023||15:00||A.F.C. Bournemouth v Manchester City|
|04/03/2023||15:00||Manchester City v Newcastle United|
|11/03/2023||15:00||Crystal Palace v Manchester City|
|18/03/2023||15:00||Manchester City v West Ham United|
|01/04/2023||15:00||Manchester City v Liverpool|
|08/04/2023||15:00||Southampton v Manchester City|
|15/04/2023||15:00||Manchester City v Leicester City|
|22/04/2023||15:00||Brighton v Manchester City|
|26/04/2023||20:00||Manchester City v Arsenal|
|29/04/2023||15:00||Fulham v Manchester City|
|06/05/2023||15:00||Manchester City v Leeds United|
|13/05/2023||15:00||Everton v Manchester City|
|20/05/2023||15:00||Manchester City v Chelsea|
|28/05/2023||16:00||Brentford v Manchester City|
City's post-World Cup run could define title race
This promises to be a season like no other, with the campaign split into two parts with a World Cup sandwiched in-between, but Manchester City can be reasonably content with the way their Premier League fixtures have fallen.
Pre-Qatar 2022, City have a relatively kind run of games as they aim to build a lead at the top of the table, with their toughest home matches coming against Tottenham and Manchester United.
The one fixture that stands out before the turn of the year is the visit to Liverpool, which comes immediately after a Champions League group game.
Depending on how successful Pep Guardiola's players are at the World Cup, they could be rushed back into a tricky run of fixtures after Christmas, with Leeds, Chelsea and United away in the space of two-and-a-half weeks.
But City have been handed a relatively kind run-in, with four of the last five games against Fulham, Leeds, Everton and Brentford, which could in turn boost their Champions League hopes presuming they reach the semi-finals once again.
15/10/22.— GOAL (@goal) June 16, 2022
Mark your diaries for the first Premier League showdown between Liverpool and Manchester City 🍿 pic.twitter.com/Vo6hChjJiL
When do Man City play Liverpool in 2022-23?
Last season's top two will again be the title favourites heading into 2022-23, meaning that their matches against one another are likely to be key in deciding who lifts the trophy in May.
They will meet for the first time on Saturday, October 15 at Anfield, with the return fixture at the Etihad Stadium coming late in the season, on Saturday, April 1.
Both games in 2021-22 finished in 2-2 draws.
When do Man City play Man Utd in 2022-23?
The first Manchester derby of the 2022-23 season takes place on Saturday, October 1 at the Etihad Stadium.
Erik ten Hag's first taste of an Old Trafford derby, meanwhile, will be played on Saturday, January 14.
City won both derbies in 2021-22, so United will no doubt be out for revenge and local bragging rights when the matches come around.
Man City tickets: Prices & how to buy
Tickets for Man City Premier League games can be bought through official club channels.
Games are divided into categories, depending on the opponent, with prices varying according to category and seat position. Games against Tottenham, Chelsea, Liverpool, Manchester United and Arsenal, for example, are more expensive.
Man City season tickets for 2022-23 are now sold out.
You can find out more about buying tickets for Man City games on the official club website.
Man City 2022-23 pre-season fixtures & results
Before they begin their season in earnest, Man City will play a number of pre-season friendlies.
Guardiola's side will play Club America (July 20) and Bayern Munich (July 23) in the United States.
They will then raise the curtain on the English season in the Community Shield against Liverpool on July 30.