Taking their place in the tournament after winning the Africa Cup of Nations earlier this year, Hugo Broos' team are available at 9/2 (5.50) with dabblebet to get off to the best possible start by coming out on top at the Otkrytiye Arena.
However, La Roja have won two consecutive Copa America championships, and are 6/10 (1.60) favourites to collect maximum points here.
The sides shared a 1-1 draw when they last met in the 1998 World Cup, and you can get odds of 3/1 (4.00) on them cancelling each other out once again on this occasion.
Having qualified following a second consecutive AFCON victory, Les Lions Indomptables' last appearance in this competition saw them suffer an extra-time defeat against France in the 2003 final.
Although widely accepted as the best team in Africa back then, this year's continental triumph came as more of a surprise - built on a disciplined team ethic and few standout stars.
Broos' men scored just seven goals in their six matches en route to the trophy in Gabon, a feat made possible by a backline than conceded just three times in that run.
However, last week's 4-0 friendly thrashing at the hands of Colombia suggests this defensive approach may not hold out against an attack spearheaded by the irrepressible Alexis Sanchez.
Nevertheless, with Juan Antonio Pizzi's side having conceded three times against Romania that same evening to make it just one clean sheet in five, it seems unlikely that either defence will put up too much resistance.
With this in mind, even odds (2.00) seem generous on over 2.5 goals being scored for Cameroon's third game in four and a fourth in five for Chile.