It’s been a disappointing start to the season for the home side who sit 10th domestically, as opposed to the visitors who are flying high and are top of the table having taken maximum points from their seven games.
Bearing the Red Bull brand isn't the only thing these teams have in common. Their recent matches have been hugely entertaining and that propensity for goals looks set to continue on Thursday evening.
Leipzig have played five competitive matches at home this season, two in the Bundesliga and three to qualify for the group stages of this competition.
Both teams to score has landed in four of those games and overall they contained 20 goals. The home side were responsible for 14 of those but their defence has been exposed on plenty of occasions already this term.
Ralf Rangnick's men went to Borussia Dortmund and were thumped 4-1 on matchday one, meaning they have only kept out two of 10 opponents they've faced in all competitions home and away this campaign.
That defensive fragility is unlikely to go unpunished despite their position as odds-on favourites in the match odds market.
Over 3.5 goals is an 8/5 (2.60) chance with 888Sport and the form of the visiting team suggests that could be a great selection for this game.
Salzburg's last four matches - covering the Swiss top-flight and a Champions League qualifier - have contained 17 goals. Both teams scored in each of those games and plenty more action looks assured in a meeting between two such top-heavy sides.