Leganes travel to the Wanda Metropolitano on Wednesday for their first ever match in Atletico Madrid's new stadium.
Los Pepineros had great success when they visited the Bernabeu in the Copa del Rey last month and will be hoping for another shock to derail Atleti's title push.
Latest odds
Diego Simeone's men are unbeaten in La Liga in their new home and bet365 offer them at 2/11 (1.22) to record another win.
Leganes, meanwhile, can be backed at 20/1 (21.00) to claim a famous victory, with the draw available at 9/2 (5.50).
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Team news
Left-back Lucas Hernandez has missed Atletico's last couple of games and remains a doubt for this encounter.
Stefan Savic is the only other injury concern for Diego Simeone, who may chose to rotate his squad given Atletico visit the Camp Nou for a key game in the title race on Sunday.
Striker Claudio Beauvue could miss out with the injury that kept him out of Leganes' weekend draw with Las Palmas.
Atletico to grind out another win
Los Rojiblancos boast the best defensive record in La Liga, and at home they have conceded just four goals in 12 games - whilst bagging only 17 themselves.
Leganes have netted just 21 times in 25 games and have scored just one goal in their last six competitive matches, which goes some way to explaining the enormous price of 5/2 (3.50) for both teams to score.
Tips and predictions
The smart money, though, should be going on another low-scoring Atleti win.
A victory for Los Rojiblancos and under 2.5 goals is available at a tempting looking 13/10 (2.30), with this selection paying out in six of Atletico's eight home league wins this season.
Odds correct at the time of writing. Please gamble responsibly.
Atletico Madrid to win & under 2.5 goals at 13/10 (2.30) with bet365 for a 1.5pt stake