Keane, known for his unfiltered opinions, expressed his frustration during the match while being part of a YouTube watch-along for The Overlap alongside Gary Neville, Jamie Carragher and Ian Wright.
"I tell you what, Rashford has come on, his general play as a footballer is shocking. Watch his header there," he said.
"You know what that is, rubbish! That is f***ing rubbish... kicks it out of play."