The full-back was seriously injured during training for PSV last Saturday and faces an extended period on the sidelines, with some reports suggesting he is unlikely to return until the turn of the year.
The development poses something of a conundrum for PSV, who were keen to make Dest's loan move from Barcelona permanent for a reported €10m fee, but are now faced with the prospect of making a big investment for a player who faces a long road back to fitness.
Dutch outlet Voetbal Primeur reports that the club's hierarchy remain keen on the deal and will attempt to negotiate a lower fee with their Spanish counterparts.