Injury to Bukayo Saka has left the southerners in desperate need of star power, but they at least have some defensive steel to call upon, headlined by his Arsenal colleagues William Saliba and Gabriel Magalhaes. The Gunners' third starter is Martin Odegaard, who has largely underwhelmed this season but brings some requisite reputation and quality to the team.
Cole Palmer, obviously, makes the cut, as does fellow Chelsea midfielder Moises Caicedo. They are, though, the Blues' only two starters after going off the boil in recent weeks.
There is then a drop-off in top-line talent due to the strangeness of the season so far. Looking at you mostly, Tottenham, with your one starter of Pedro Porro at right-back. On the other flank, United States star Antonee Robinson of Fulham gets the call over Bournemouth's Milos Kerkez, partly based on his performances but with the added bonus of fittingly having an American in this game.
In goal, David Raya is off limits from the starting XI, and most of the south's other shot-stoppers are either out of form or injured. Still, at least Dean Henderson is looking a bit more like his Sheffield United-self down at Crystal Palace. So, every cloud.
Up top is where this team gets super wicked strange. The decision to overlook Arsenal's other attackers was an easy one, while those at Chelsea and Spurs have been far too hit-or-miss to deserve selection from the start. With that in mind, we're deferring to the modern day streets-won't-forget trio featuring Brentford double act Bryan Mbeumo and Yoane Wissa, plus Bournemouth's Antoine Semenyo.
Mikel Arteta will coach the south side, and as a treat, he will be allowed to bring set-piece coach Nicolas Joever with him. A healthy mix of southern clubs are represented among the subs.
South XI
Dean Henderson; Pedro Porro, William Saliba, Gabriel Magalhaes, Antonee Robinson; Moises Caicedo, Martin Odegaard, Cole Palmer; Bryan Mbeumo, Yoane Wissa, Antoine Semenyo.
Substitutes: David Raya, Malo Gusto, Milos Kerkez, Declan Rice, Dejan Kulusevski, Justin Kluivert, Joao Pedro, Jean-Philippe Mateta, Raul Jimenez (Manager: Mikel Arteta).