The home side have become regulars in this competition, having appeared in 11 of the last 13 editions. Last season they reached the last 16 stage but were edged out by Roma over two legs. 888Sport offer 19/20 (1.95) about a home win in this game and it's easy to see why the hosts are a shade of odds on.
The obvious play here though, is goals - and lots of them. Shakhtar have failed to keep a clean sheet in their last 10 matches in this competition and the visitors undoubtedly have the attacking options to contribute to a high-scoring affair.
Hoffenheim were the second most potent side in the Bundesliga last term (66 goals) behind runaway winners Bayern Munich. However, Julian Nagelsmann's team had the defence of a bottom half side despite finishing third overall, leaking 48 times in 34 league games. Both teams to score is just 11/20 (1.55).
The last time the hosts failed to score twice in front of their own fans in European competition was back in 2015 against Paris Saint-Germain. In the following seven games they've recorded six victories but more importantly - racked up 18 goals.
Given that trend, the insdustry-best 49/20 (3.45) on a home win featuring goals at both ends with 888Sport looks well worth backing. Not least because the visitors are making their debut in the group stages of this competition.
If a home win is available at 19/20 (1.95), adding the stipulation that Nagelsmann's side get on the scoresheet adds a serious boost to the potential returns yet it happens with regularity in their matches against better teams.
This bet landed in each of Hoffenheim's three tips to fellow top four sides in the Bundesliga last season and another high scoring win looks a tasty selection at 49/20 (3.45).