Pep Guardiola's men beat Cardiff City 2-0 on Sunday to set up a tie with Paul Cook's side, who have a two-point lead at the top of English football's third tier and have already knocked two Premier League sides out of the competition this season.
The Premier League leaders will be hoping to avoid a similar outcome to the 2013 final against the same opposition, when Ben Watson headed Roberto Martinez's Wigan to a late victory against a City side coached by Roberto Mancini.
West Brom will host Southampton in the round's only confirmed all-Premier League encounter, while Leicester City will host Sheffield United and Swansea must navigate a replay with Notts County on Tuesday February 6 to set up a tie with Sheffield Wednesday.
|Feb 17-18||Sheffield Wednesday vs Notts County/Swansea City|
|Feb 17-18||West Bromwich Albion vs Southampton|
|Feb 17-18||Chelsea vs Hull City|
|Feb 17-18||Leicester City vs Sheffield United|
|Feb 17-18||Huddersfield Town/Birmingham City vs Manchester United|
|Feb 17-18||Millwall/Rochdale vs Newport County/Tottenham|
|Feb 17-18||Brighton and Hove Albion vs Coventry City|
|Feb 17-18||Wigan Athletic vs Manchester City|