The club said: "Bayer 04 will have to manage without Florian Wirtz. The Germany international suffered a ligament injury in his right ankle in the home game against Werder Bremen (0-2) on Saturday. That was the diagnosis from an MRI scan following the game. The 21-year-old midfielder will be out of action for several weeks."
Speaking on Wirtz's injury, Leverkusen managing director Simon Rolfes added: "The loss of Florian obviously hits us hard in this phase of the season but we will compensate for him with a strong squad. We know Florian and also know he will come back as soon as possible. Everybody will support him in that. We are assuming he will be fully fit again for the end of the season run-in."