Winger Samuel Chukwueze scored a brace inside the opening 21 minutes, while midfielder Tijani Reijnders bagged an effort in the 17th minute as well. Forward Rafael Leao added their fourth in the 23rd minute to round out the first 45 minutes.
Come the second half, defender Davide Calabria added their fifth, while striker Tammy Abraham bagged the sixth in the 62nd minute.
Sassuolo's lone effort arrived in the 59th minute through strike Samuele Mulattieri.