Cristiano Ronaldo will come up against some familiar faces when he leads his country in their first group game at the World Cup.
The Real Madrid forward is the highest scoring player in the history of the Portuguese national team and he will be hoping to open his account in Russia.
A strike here would see him become just the fourth man to score at a fourth different World Cup, joining Pele, Uwe Seeler and Miroslav Klose in the record books.
Latest odds
Ronaldo is the shortest priced Portuguese player to find the back of the net with dabblebet offering him at 7/5 (2.40).
Any time the 33-year-old is priced at odds-against to score it is worth considering, while he can be backed at 4/1 (5.00)to open the scoring.
Behind him in the betting in Goncalo Guedes, who spent this year on loan at Valencia and is priced at 23/10 (3.30)to score, while Milan's Andre Silva is offered at 11/4 (3.75).
Who will start for Spain?
Julen Lopetegui had previously admitted he did not know who would start the Portugal game at striker for Spain, but it will now be down to new coach Fernando Hierro to make the decision.
dabblebet cannot separate Spain's three out-and-out strikers, with Diego Costa, Rodrigo Moreno and Iago Aspas all offered at 9/2 (5.50)to score first and 8/5 (2.60)to score at any time.
Of the three, Aspas seems to be in the best form and fits the Spain system well, although it is tough to know whether he will feature especially given all the upheaval surrounding the team.
Tips and predictions
With plenty of question marks around who will play up front for La Roja there is perhaps more value in backing one of their hugely talented midfielders to score.
Isco is priced at 11/5 (3.20)to score at anytime and the Real Madrid player has been in excellent scoring form for his country, netting seven times in his last seven international games.
Isco to score at anytime at 11/5 (3.20) for a 0.5pt stake with dabblebet 