The French World Cup winner only returned to training on Monday following his exploits with his national side in Russia this summer but has been selected by Jose Mourinho for the first game of the league season.
Despite reports of friction between the midfielder and the manager, Pogba comes in as the only change from the side which lost to Bayern Munich in their final pre-season game on Sunday with Ander Herrera missing out with a hamstring injury.
United also have a number of returning World Cup stars on the bench, with Ashley Young, Marouane Fellaini and Romelu Lukaku all on standby.
Leicester name United summer target Harry Maguire among their starters, while fellow England World Cup star Jamie Vardy is on the bench alongside new signing and former United player Jonny Evans.
Man Utd XI: De Gea; Darmian, Bailly, Lindelof, Shaw; Pogba (c), A Pereira, Fred; Mata, Rashford, Sanchez. Subs: Grant, Smalling, Young, Fellaini, McTominay, Martial, Lukaku.
Leicester City XI: Schmeichel; Ricardo, Morgan (c), Maguire, Chilwell. Amartey, Silva, Ndidi, Maddison Gray, Iheanacho. Subs: Ward, Evans, Vardy, Albrighton, Iborra, Fuchs, Ghezzal.