Maurizio Sarri is facing his busiest run in the league and is locked in a battle for a top-four place, with his side remaining outsiders to win the Premier League title due to City's seven-point advantage over them.
Nuno Espírito Santo will want to see his Wolves side stop their slide down the table at Molineux after picking up just one point from their last six games.
Chelsea brought back Eden Hazard against Fulham after he sat out some training sessions and the Europa League match against PAOK last week. He has recovered from his ankle injury and Ross Barkley is also expected to return from a knock he sustained last Thursday.
Victor Moses is also a doubt with a back problem, but Chelsea will likely see Mateo Kovacic return from tiredness after he was brought off for Ruben Loftus-Cheek in the 2-0 win over Fulham.
Marcos Alonso also picked up an ankle problem against Fulham and he was substituted for Davide Zappacosta in the second half. However, Sarri thinks that he will still be in contention to face Wolves and he will check his condition ahead of the game.
"I want to speak to him. But he didn't play very well," Sarri told a news conference ahead of the game. "I know very well this, but I think Alonso knows very well this, also. It can happen.
"Today we will see the reaction, we will see the situation with the back. For the doctor, his back is better.”
Chelsea don't have any players out through suspension ahead of Wednesday's clash, while there are no players in danger of bans should they pick up yellow cards. N'Golo Kante, Alvaro Morata and Antonio Rudiger have the most bookings this season for the Blues, with three apiece.
However, Wolves are without their influential midfielder Ruben Neves, who is suspended for collecting his fifth yellow card in the 2-1 defeat to Cardiff City on Friday night.
Chelsea Potential Starting Line-Up
Chelsea have been fairly consistent in their team selections in the Premier League season but that might change against Wolves.
Sarri may look to rotate some players as he faces 12 games in 40 days during English football's busy winter schedule. Chelsea's next opponents after this match - Man City - will pose a concern as the most powerful team in the division so changes could be made against Wolves.
Alvaro Morata and Willian sat out the last game against Fulham and could come back in to face Wolves. Loftus-Cheek has put in two strong back-to-back performances and he has five goals in his last six Chelsea appearances, which may lead to him getting a chance in midfield.
Wolves Team News
As well as Neves' absence through suspension, Wolves will be without their wing-back Jonny, who picked up a knee injury while on international duty with Spain.
TV channel & kick-off time
The match at Molineux kicks off at 7:45pm GMT (2:45pm ET) on Wednesday and it will not be shown on TV in the UK.
Best Opta Match Facts
Chelsea have won their last four meetings with Wolves in all competitions by an aggregate score of 13-1.
Chelsea have lost just one of their last 13 away league games against promoted sides (W10 D2), though it was in their last such match against Newcastle last season. They’ve not lost consecutive away games vs promoted sides since December 1999 (vs Watford and Sunderland).
Wolves have lost their last three Premier League games at Molineux, last losing four on the bounce on home soil in league competition in November 2016.
Only Raheem Sterling (14) has been directly involved in more Premier League goals this season than Chelsea’s Eden Hazard (12 - 7 goals, 5 assists).
Chelsea’s Pedro has scored more league goals in 12 appearances this season (5) than he netted in 31 league matches in the whole of 2017-18 (4).