Sergio Ramos and Gareth Bale will not feature in Real Madrid's match against Malaga on Saturday despite returning to training.
Ramos, who suffered a broken nose in the draw against Atletico Madrid, took part in Madrid's Friday session wearing a protective mask but has not been included on Zinedine Zidane's squad list.
And Bale will be given more time to return to match fitness having made his comeback to training on the same day after a thigh injury.
Zidane has Keylor Navas and Mateo Kovacic at his disposal, though, after the goalkeeper and midfielder recovered from groin injuries.
Marco Asensio will not be risked due to a minor problem and Madrid will also be without the suspended Nacho.
Bale has made just five appearances in La Liga this season having suffered his thigh injury shortly after recovering from a calf ailment that kept him out for approximately six weeks.
"We know what [Bale] can give us," Zidane told the media on Friday. "He’s very strong, powerful and technically good.
"He’s worked hard and has done very well in the matches he has played with this club. There's a lot of talk that he's injured, that he has spent a lot of time out, playing three games and then missing one.
"But he’s very important for us. He knows that, I know it and everyone else does.
"I don’t know when he’ll play. Today he's trained with us, he's in fine shape physically and not in pain. We'll see when he's going to play."
He added: "I prefer to have Gareth available, obviously. He can give us his strength, he’s very good, fast, he's a crosser and works hard. He brings a lot to the team.
"The important thing for everyone and for his mood is that he is with us and that he starts playing. That can take away the negative things that could be around him."
That will give the defending champions a chance to make up ground on at least one of the teams above them if they can win against 18th-place Malaga.
"One of the two will drop points," Zidane said of the Valencia-Barcelona match. "I’m interested in our match, get the three points and then see what happens on Sunday in that game.
"Something will happen for sure. I didn’t imagine being 10 points behind. Every match is decisive. We're on the right track, we have a lot of energy and we’re positive.
"We have a disadvantage, but these games are going to be important."