There was little to separate the two teams until a cross came into the Guinea-Bissau box in the first half and defender Opa Sangante lashed at it, inadvertently sending it into his own goal.
Nigeria had a great chance to double their lead when Moses Simon was sent through on goal just two minutes into the second-half but goalkeeper Jonas Mendes did a great job in getting low to stop the winger. Seconds later, Mendes came rushing out to prevent Victor Osimhen from getting onto the ball and causing some trouble.
Nigeria kept knocking at the door and shortly after Osimhen saw a difficult header just miss the target, the Napoli star fired in his team's second goal but it was ruled out by the referee. Osimhen had another chance to score when Ola Aina whipped in a great cross but the forward's header went wide again.
Guinea-Bissau thought they had pulled level late on through Franculino Dju but the assistant's flag denied him. Nigeria responded by lashing in another goal but it was also disallowed and the Super Eagles held out for the 1-0 win.