Sundowns duo of Gift Motupa and Rivaldo Coetzee are expected to miss this crucial encounter due to their respective injuries.
While Bradley Ralani and George Maluleka missed Downs' 2-1 defeat to Petro on April 16 because of minor injuries and they should feature this weekend.
The 2016 African champions have no suspension concerns heading into this second-leg match which will be played at FNB Stadium.
GOAL takes a look at how the Tshwane giants' could start against the Tricolours.
Mamelodi Sundowns.
