The England international is preferred to Anthony Martial on the left-hand side, while Wayne Rooney, Juan Mata and Jesse Lingard are also on the bench.
Martial's exclusion comes after the Portuguese manager was not suitably impressed by the winger's two assists in Sunday's win having left him out of the previous two fixtures.
MAN UTD: De Gea; Valencia, Jones, Rojo, Blind; Carrick (c), Herrera; Mkhitaryan, Pogba, Rashford; Ibrahimovic. Subs: Romero, Mata, Rooney, Martial, Smalling, Lingard, Young.
HULL CITY: Jakupovic, Robertson, Maguire, Meyler, Huddlestone, Clucas, Dawson (c), Niasse, Tymon, Evandro, Markovic. Subs: Marshall, Hernandez. Ranocchia, Elabdellaoui, Maloney, Diomande, Bowen.