The 39-year-old joined the Old Lady back in 2001, and has lifted the Serie A title seven times while finishing runner-up in the Champions League on two occasions.
And he has now reached a century of appearance in the European competition, a feat attained by just one other Italian for the same club.
100 - Gianluigi Buffon is only the 2nd Italian player to reach 100 #UCL appearances for the same team after Paolo Maldini. Captains.— OptaPaolo (@OptaPaolo) 3 de mayo de 2017
Only Paolo Maldini has played 100 Champions League matches for one side, during his incredible career at AC Milan.
The legendary left-back made a total of 106 appearances for the Rossoneri in the competition, a tally that will surely be surpassed by his former Italy team-mate.
Buffon and Juventus can still mark a treble in 2016-17, as they remain competitive in three competitions.
Massimiliano Allegri's men could be crowned Serie A champions for the sixth consecutive campaign at the weekend, while they are also in the final of the Coppa Italia.