Trent Alexander-Arnold:
Liverpool's home-grown hero made his first Premier League start at Old Trafford, but his memories of this famous old ground are not all good.
Remember the chasing he got at the hands of Marcus Rashford here in 2018? There were shades of that this evening. Rashford was on the pitch again, but it was Anthony Elanga who was Alexander-Arnold's tormentor-in-chief.
The young Swede had the England full-back running scared in the first half. Elanga should have taken advantage of Alexander-Arnold's absence to score himself early on, but hit the post. No worries, he picked himself up and got in again down the United left, setting up Sancho for the opening goal.
Alexander-Arnold, who had escaped a booking for an early foul on Rashford, would soon after pick up a booking for tripping Elanga just outside the penalty area. He improved in the 15 minutes before half time, but by then the damage had been done, and in the second half he again struggled to get to grips with a rejuvenated Rashford.
He'll want to forget this night as quickly as he forgot the one four years ago.
Virgil van Dijk:
What's wrong with Liverpool's rock? The Dutchman just hasn't looked himself so far this season, as evidenced against Fulham's Aleksandar Mitrovic on the opening weekend, and this was another worrying evening.
His refusal to close down Sancho for United's opener was strange, and led to some furious words exchanged with James Milner. Van Dijk was also caught on his heels by Anthony Martial for the second goal, albeit from a wayward touch from Jordan Henderson.
With their defensive lynchpin struggling, Liverpool are struggling. They need the old Van Dijk back, and quick.
Naby Keita:
The question has to be asked: just what is going on with the Guinea midfielder? Keita was not a part of the Liverpool squad here, left out amid growing speculation he could be set to leave the club.
Reds sources - and indeed sources close to the player - insisted his absence was down to an injury, which was either extremely ill-timed or very convenient, depending on your level of cynicism. Keita was on the bench against Crystal Palace last week, and trained as normal with his team-mates on Saturday, but he didn't even travel with the squad here.
Cause for concern? Certainly, given Liverpool's current dearth of midfielders. And with reports emanating from Germany that the 27-year-old is unhappy with his current situation - he has less than a year left on his contract - there has to be at least a degree of doubt now as to whether Keita will be at Anfield come September 1.
Last week, Liverpool strongly dismissed the idea of him leaving, a stance reiterated by Klopp at his pre-match press conference on Friday. "If Naby leaves - which he won't - there would need to be a replacement," he said.
Who knows, maybe we will see some late transfer business at Anfield after all?
Darwin Nunez:
A few minutes before half-time, the TV cameras panned to the Old Trafford stands, where Liverpool's new £64 million ($76m) signing sat, tracksuited and glum-faced.
If Nunez hadn't already realised the folly of his decision to react to Joachim Andersen's wind-up act at Anfield last week, then he certainly will have done tonight. These were the games he would have dreamed of when joining the Reds, and yet there he was, twiddling his thumbs while his under-pressure team-mates toiled.
He'll learn from his mistake, of course, but it was a good move from Liverpool to bring him along to this game.
Look at what you could have won, Darwin. Your team needed you.