Ten Hag also invoked the memorable 2-1 triumph in the previous Premier League season at Old Trafford to further boost the morale of his troops.
"This fixture always demands concentration, calm and confidence," he explained.
"Every player, whether in the starting XI or on the bench, has a job to do and has to take responsibility for doing it correctly.
"We also had incredible support from the stands when we beat Liverpool at Old Trafford last season and we know, from that experience and other big games, what a difference the fans can make when we really bring the noise.
"I don’t need to explain to anybody the significance and size of this game. We have the two greatest clubs in English football, with the greatest pedigree and the greatest rivalry, facing each other in a knockout tie in the world’s greatest cup competition. When you are a child watching football, these are the games that make you fall in love with the sport; how could anybody not be excited to be a part of this spectacle?"